WebWhile the ATR pathway is known to transmit DNA damage signals through the ATR-Chk1 kinase cascade, ... Multiple ATRIP-interacting proteins, including ATR, RPA70, TopBP1, and the MRE11-RAD50-NBS1 complex, exhibit reduced binding to the ATRIP SUMOylation mutant in cells and display affinity for SUMO2 chains in vitro, ... Web*Darkness represents the genes rank within the SuperPath, via the multiplicity of each gene in the constituent pathways.

ARGs as potential biomarkers & therapeutic targets in AF IJGM

Web(D) The Slx4–Dpb11 interaction is regulated by cell cycle phase and DNA damage. Experiment as in C but with G1- and G2/M-arrested cells, which were either damaged by 50 μg/mL phleomycin or left untreated. (E) Binding of human Slx4 and TopBP1 is regulated by CDK phosphorylation. WebApr 11, 2011 · Although we showed that the fifth BRCT domain (BRCT5) of TopBP1 is required for TopBP1 focus formation after DNA damage (Yamane et al., 2002), the identity of an upstream regulator that would bind to TopBP1 BRCT5 and facilitate the recruitment of TopBP1 to DNA damage sites remains elusive. michel teytu

Andrew Blackford - Principal Investigator - University …

WebTOPBP1 DNA damage meiosis meiotic silencing spermatogenesis M eiosis is the … WebIt is also likely that coupling of DNA synthesis with cellular metabolism may involve interactions of replication proteins with other macromolecular complexes, responsible for various cellular processes. Thus, the exact set of factors participating in triggering the replication initiation may differ depending on growth conditions. WebApr 22, 2012 · Widespread DNA damage in Topbp1 Emx1-cre mice is shown by γH2AX … michel thamin pagexl