WebJul 18, 2024 · Single-stranded DNA (ssDNA) binding proteins (SSBs) are critical in maintaining genome stability by protecting the transient existence of ssDNA from damage during essential biological processes, such as DNA replication and gene transcription. The single-stranded region of telomeres also requires protection by ssDNA binding proteins … DNA-binding proteins can incorporate such domains as the zinc finger, the helix-turn-helix, and the leucine zipper (among many others) that facilitate binding to nucleic acid. There are also more unusual examples such as transcription activator like effectors . Non-specific DNA-protein interactions [ edit] See more DNA-binding proteins are proteins that have DNA-binding domains and thus have a specific or general affinity for single- or double-stranded DNA. Sequence-specific DNA-binding proteins generally interact with the See more DNA-binding proteins include transcription factors which modulate the process of transcription, various polymerases, nucleases which cleave DNA molecules, and histones which are involved in chromosome packaging and transcription in the See more In contrast, other proteins have evolved to bind to specific DNA sequences. The most intensively studied of these are the various transcription factors, … See more • bZIP domain • ChIP-exo • Comparison of nucleic acid simulation software • DNA-binding domain See more Structural proteins that bind DNA are well-understood examples of non-specific DNA-protein interactions. Within chromosomes, DNA … See more A distinct group of DNA-binding proteins are the DNA-binding proteins that specifically bind single-stranded DNA. In humans, See more Protein–DNA interactions occur when a protein binds a molecule of DNA, often to regulate the biological function of DNA, usually the expression of a gene. Among the proteins that bind to … See more
Structure and function of DNA-binding proteins
WebJan 15, 2003 · The structures of very small protein domains are generally stabilized by the formation of disulfide bonds, or by binding to metal ions (most frequently, zinc). Metal binding increases the thermal and conformational stability of small domains but typically is not directly involved in their function. WebMay 28, 2004 · Sterol regulatory element binding protein la (SREBP-1a; Figure 1c) is an example of a bHLH structure that includes one of the additional domains, the leucine zipper. SREBPs are bHLHZ transcription activators that bind to a DNA target site as a homodimer and are essential for cholesterol metabolism [ 27 ]. bright minds daycare moseley
Structural features of the single-stranded DNA-binding protein MoSub1 …
WebNov 2, 2024 · DNA-binding proteins play a very important role in the structural composition of the DNA. In addition, they regulate and effect various cellular processes like transcription, DNA replication, DNA recombination, repair and modification. The experimental methods used to identify DNA-binding proteins are expensive and time … WebJul 2, 2013 · These comparisons reveal the structural features that define the range of functions exhibited by these proteins. The appropriate recognition and processing of single-stranded DNA (ssDNA) require a diverse set of binding proteins. ... Single-stranded DNA-binding protein (SSB) is generally thought of as a bacterial homolog to RPA, ... WebNov 16, 2013 · Binding of proteins to particular DNA sites across the genome is a primary determinant of specificity in genome maintenance and gene regulation. DNA-binding specificity is encoded at multiple levels, from the detailed biophysical interactions between proteins and DNA, to the assembly of multi-protein complexes. bright now dental lawrenceburg in