WebSep 23, 2024 · CTGF, a downstream molecule of TGF-β/Smad, is a novel profibrotic factor that is up-regulated in the glomerulosclerosis of DN. Recent studies have identified that CTGF promotes the abnormal deposition of ECM and fibrosis and thus could enhance the disassembly and hypertrophy of mesangial cells [ 17 ]. WebConnective tissue growth factor (CTGF) plays a critical role in the hepatic stellate cells (HSCs)-mediated development of hepatic fibrosis. Nevertheless, the e
Connective Tissue Growth Factor Is Increased in Plasma of Type 1 ...
WebNov 14, 2012 · Diabetic nephropathy, also known as Kimmelstiel-Wilson syndrome or nodular diabetic glomerulosclerosis or intercapillary glomerulonephritis, is a clinical syndrome characterized by albuminuria (>300 mg/day or >200 mcg/min) confirmed on at least two occasions 3-6 months apart, permanent and irreversible decrease in glomerular … WebConnective tissue growth factor (CTGF) is a potent inducer of extracellular matrix accumulation. In diabetic nephropathy, CTGF expression is markedly upregulated both in podocytes and mesangial cells, and this may play an important role in its pathogenesis. binary editor online free
Unraveling the role of connective tissue growth factor in diabetic ...
WebConnective tissue growth factor (CTGF) is a potent inducer of extracellular matrix accumulation. In diabetic nephropathy, CTGF expression is markedly upregulated both in podocytes and... WebMar 27, 2024 · The diabetic chronic kidney disease (CKD) model in this study utilized uninephrectomy, high fat diet and one dose of streptozotocin which closely simulates human type 2 diabetic nephropathy. 25, 26 Male Sprague–Dawley rats (body weight 225–250 g, Charles River) were subjected to right nephrectomy under inhaled isoflurane anesthesia. WebJun 1, 2008 · Recently, CTGF has emerged as an important factor in diabetic nephropathy. In renal cells, CTGF is induced by high glucose, and it is critically involved in diabetes-associated changes such as extracellular matrix synthesis, cell migration, and epithelial-to-mesenchymal transition ( 5 – 8 ). cypress hill comic book